Role of Collagen in the Human body

Collagen is the most enormous protein in the human body, it is found in the bones, muscles, skin, and tendons. It is the protein that holds the body together. Collagen forms a scaffold for providing strength and structure. Endogenous collagen is a natural collagen synthesized by the body. It is naturally found. Exogenous collagen is synthetic. It comes from an outside source, such as food supplements or any other supplements.
Endogenous collagen has several important activities in our body. If it is depleted or breakdown by any cause, it will lead to several health problems. Exogenous collagen is usually used for medical and cosmetic purposes, to repair of the body tissues.

What are the facts of Collagen?

1) Collagen happens throughout the body, especially in the skin, bones, and connective tissues.
2) Some types of collagen fibrils, gram-for-gram, are stronger than steel.
3) Collagen production declines with age, and it is affected by external factors such as smoking and UV light.
4) Collagen can be used in collagen dressings, for attracting new skin cells to wound sites.
5) Cosmetic lotions that claim for increasing collagen levels are unlikely to do so, as collagen molecules are so large that it is to be absorbed through the skin.

What is Collagen?

Collagen is a hard, insoluble, and fibrous protein which fulfills up to one-third of the protein in the human body. They provide skin strength and elasticity. There are 16 different types of collagen. They have different structures and functions.

What does collagen do?

Collagen is formed by various cells. It is connected by tissue cells. In the dermis or the middle layer of our skin, collagen helps to create a fibrous network of cells called fibroblasts, upon that new cells can grow. It also plays a role in replacing and restoring dead skin cells. With the increasing of age, our body produces less collagen.

What are the uses of collagen?

Collagen is used in both medical and cosmetic purposes.

1) Skin Fillers: Collagen injections can improve the tone and brightness of the skin and control depressions. Fillers that contain collagen are used cosmetically for removing lines and wrinkles from the face. It can also develop scars, as long as these do not have a sharp edge. These fillers are originated from humans and cows. Skin tests must be done before using collagen from cows to avoid aggravating any allergies.

2) Wound Dressing: Collagen helps to heal wounds by attracting new skin cells to the wound site. It promotes to improve and provides a platform for new tissue growth
a) Chronic wounds that are not responding to other treatment
b) wounds that expel of the body fluids such as urine or sweat
c) partial and full-thickness injuries
d) second-degree level burn

3) Guided tissue regeneration: Collagen-based membranes can help to heal in these cases, and they are reasonable, so this barrier does not need to be omitted after the primary operation.

4) Vascular prosthetics: Collagen tissue grafts from donors have been used in peripheral nerve regeneration, for vascular prostheses, and in arterial reconstruction.

5) Treatment of Osteoarthritis: Collagen formulations help to treat osteoarthritis.

6) Skin Revitalization: Many products contain collagen, including creams and powders, claim to empower the skin by increasing collagen levels within the body.

Preventing Collagen Loss: A healthful diet helps the body producing collagen
1) Proline: Egg whites, meat, cheese, soy, and cabbage
2) Anthocyanidins: blackberries, blueberries, and cherries
3) Vitamin C: Oranges, strawberries, peppers, etc
4) Copper: nuts, red meat, and drinking water
5) Vitamin A: Animal foods and plant foods

What are the factors that damage collagen?

Some factors which reduce the production of collagen in our body. Just to avoid them to be a healthy and long life of skin

1) High Sugar Consumption: A high sugar diet is increasing the rate of glycation, which attaches with protein to form a new molecule. This will affect the production of collagen
2) Smoking: Many chemicals that are present in tobacco smoke definitely damages the collagen and elastin in the body. On the other side, nicotine also narrows the blood vessels of our skin.
3) Sunlight: UV ray of the sun breaks the collagen formation rapidly. The UV rays damage the collagen in the dermis layer of our skin
4) Autoimmune disorders: Some autoimmune disease produces antibodies. These antibodies target the collagen formation.
5) Genetic changes also affect collagen formation.
6) The aging process depletes collagen levels naturally over time. There is no alternative to prevent this.

Updated: November 7, 2019 — 2:02 pm

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